2006 Mercedes-Benz E350 transmission problems
The 2006 Mercedes-Benz E350 has 37 transmission complaints filed with NHTSA — 8% of the year's total, and up sharply from the prior model year.
37
Transmission complaints
8%
Share of year
1
Crash-involved
0
Related recalls
Transmission complaints by year
What owners report
“WE, MY WIFE AND 3 SON'S WERE COMING DOWN FROM BIG BEAR WHEN IT STARTED SNOWING. SNOW GOT HEAVY AND I WAS APPROACHING A SHARP CURVE SLOWED DOWN TO ABOUT 8MILES MADE THE TURN ND SLOWLY PRESSED ON THE GAS PEDDLE, THE RPMS WENT UP BUT THE CAR DID NOT ACCELERATE. I HAD TO STOP PUT THE CAR IN PARK THEN…”
Common questions
How many transmission complaints does the 2006 Mercedes-Benz E350 have?
NHTSA has 37 complaints about the 2006 Mercedes-Benz E350 transmission — 8% of all complaints filed for that model year.
Related
Based on NHTSA ODI data through June 2026. Complaints are consumer-reported and unverified. Updated July 5, 2026.
Compiled by Sharon Ben-Moshe, Founder.