VehicleVerdict

2021 Ducati Panigale V4 S problems

Verdict · NHTSA data

Limited data — recalls on file

NHTSA has just 0 complaints on file for the 2021 Ducati Panigale V4 S — too few to judge reliability from owner reports alone — but one recall campaign applies to this year, so any used example should have its VIN checked for completed recall work.

0

NHTSA complaints

1

Recalls

0

Investigations

0

Crash-involved

0

Fires reported

0

Injuries

0

Deaths

—

NCAP overall

How does 2021 compare to other Panigale V4 S years?

Panigale V4 S NHTSA complaints by model year, 2021 highlighted5 complaints2017: 0 complaints2018: 0 complaints2019: 0 complaints2020: 0 complaints2021: 0 complaints2022: 0 complaints2023: 0 complaints2024: 0 complaints2025: 5 complaints2026: 0 complaints
Panigale V4 S NHTSA complaints by model year, 2021 highlighted. Red bars are years to avoid.

See all Panigale V4 S years to avoid →

Does the 2021 Ducati Panigale V4 S have recalls?

1 NHTSA recall campaign on file. Recall repairs are free at franchised dealers.

25V570000TransmissionSeptember 3, 2025 · 10,235 units

Defect

Ducati North America (Ducati) is recalling certain 2020-2021 Panigale V4 SL, 2019-2024 Panigale V4 R, 2018-2024 Panigale V4 S, 2023-2025 Streetfighter, 2018-2024 Panigale V4, and 2020-2022 Streetfighter V4 motorcycles. The rear wheel axle could lose its structural integrity and break.

Consequence

A rear wheel axle that breaks while riding can result in a loss of motorcycle control, increasing the risk of a crash or injury.

Remedy

Dealers will replace the rear wheel axle, free of charge. Owner notification letters were mailed October 16, 2025. Owners may contact Ducati customer service at 1-888-391-5446. The manufacturer's number for this recall is SRV-RCL-25-002.

2021 Ducati Panigale V4 S — common questions

Is the 2021 Ducati Panigale V4 S reliable?

The record is thin — 0 NHTSA complaints — so owner-report data can't strongly confirm reliability either way, though 1 recall should be verified as completed.

Does the 2021 Ducati Panigale V4 S have recalls?

Yes — NHTSA lists 1 recall campaign affecting the 2021 Ducati Panigale V4 S. Recall repairs are free at franchised dealers; check the VIN at nhtsa.gov/recalls to confirm the work was done.

Related

Based on NHTSA ODI data through June 2026. Complaints are consumer-reported and unverified. Updated July 5, 2026.

Compiled by Sharon Ben-Moshe, Founder.