VehicleVerdict

2021 Mercedes-Benz E 350 problems

Verdict · NHTSA data

Limited data — recalls on file

NHTSA has just 19 complaints on file for the 2021 Mercedes-Benz E 350 — too few to judge reliability from owner reports alone — but 12 recall campaigns apply to this year, so any used example should have its VIN checked for completed recall work.

19

NHTSA complaints

12

Recalls

0

Investigations

0

Crash-involved

2

Fires reported

0

Injuries

0

Deaths

NCAP overall

How does 2021 compare to other E 350 years?

E 350 NHTSA complaints by model year, 2021 highlighted19 complaints2020: 12 complaints2021: 19 complaints2022: 9 complaints2023: 5 complaints2024: 10 complaints2025: 4 complaints2026: 0 complaints
E 350 NHTSA complaints by model year, 2021 highlighted. Red bars are years to avoid.

See all E 350 years to avoid →

What are the most common 2021 Mercedes-Benz E 350 problems?

ComponentComplaintsShare
Driver Assistance526%
Electrical System421%
Engine421%
Fuel System316%
Transmission211%
Brakes15%

Does the 2021 Mercedes-Benz E 350 have recalls?

12 NHTSA recall campaigns on file. Recall repairs are free at franchised dealers.

23V445000Fuel SystemJune 26, 2023 · 143,551 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

Consequence

A loss of drive power can increase the risk of a crash.

Remedy

Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

22V365000OtherMay 20, 2022 · 242,722 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. An error in the communication module's SIM card software can cause a mobile network connection failure, disabling the emergency call (eCall) system.

Consequence

A disabled eCall system would prevent a vehicle occupant from contacting the emergency services call center in an emergency, potentially delaying emergency responders and increasing the risk of injury.

Remedy

The communication module software will be updated through an Over-the-Air (OTA) update or by a dealer, free of charge. Owner notification letters were mailed July 8, 2022. Owner notification letters will be mailed in phases, on July 8, 2022, May 17, 2024, July 29, 2024, and September 27, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's numbers are for this recall is 2022060005 and 2023110006.

22V232000Driver AssistanceApril 8, 2022 · 126,443 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018-2021 CLA-Class, GLE/GLS-Class, A-Class, C-Class, E-Class, E-Class Coupe/Convertible, GLA/GLB-Class, GLC-Class, and CLS-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The rearview camera may not display the rearview image due to a software error. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 111, "Rear Visibility."

Consequence

An inoperable rearview camera display reduces the driver's rear view, increasing the risk of a crash.

Remedy

Dealers will update the rearview camera software, free of charge. Owner notification letters were mailed July 15, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022060007.

22V189000SteeringMarch 25, 2022 · 8,396 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.

Consequence

Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.

Remedy

Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.

21V527000AirbagsJuly 12, 2021 · 542 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 CLS450, AMG E53, AMG CLS53, E350, E450, AMG GT43, AMG GT53, 2020 S450, S560, G550, AMG GLC63, 2020-2021 GLC300, and AMG G63 vehicles. The side crash sensor connectors may come loose, which could delay the activation of air bags and seatbelts during a side impact crash.

Consequence

Air bags and seatbelts that don't function as intended can increase the risk of injury during a crash.

Remedy

Dealers will inspect and replace as necessary, the side impact crash sensors, free of charge. Owner notification letters were mailed on September 3, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021070032/33.

21V483000Seat BeltsJune 25, 2021 · 4,917 units

Defect

Mercedes-Benz, LLC (MBUSA) is recalling certain 2021 G550, AMG G63, E350, E450, AMG CLS53, AMG E53, AMG GT43, AMG GT53, AMG GT63, 2021-2022 CLS450, and AMG E63 vehicles. The rear seat belt automatic locking retractors may deactivate early, which can prevent the child restraint system from securing properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 208, "Occupant Crash Protection."

Consequence

An unsecured child restraint system can increase the risk of injury during a crash.

Remedy

Dealers will inspect, and replace as necessary, the rear seat belt assemblies, free of charge. Owners notified of the voluntary recall campaign by an interim letter on August 13, 2021. A final letter was mailed on September 24, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.

21V354000Driver AssistanceMay 14, 2021 · 343,191 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class, GLC-Class, CLS-Class, and AMG GT-Class 4-door Coupe vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The MBUX multimedia system software may cause the display to remain black, or reboot after startup. This could result in the rearview camera image not displaying properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard (FMVSS) number 111, "Rear Visibility."

Consequence

A backup camera that displays a blank image reduces the driver's rear view, increasing the risk of a crash or injury.

Remedy

The multimedia system software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. Owner notification letters were mailed beginning June 28, 2021. Owners may contact MBUSA customer service at 1-800-367-6373. MBUSA's number for this recall is 2021050012.

21V230000Seat BeltsApril 1, 2021 · 8,634 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C-Class, E-Class, E-Class Coupe and Convertible, GLC, CLS, AMG GT 4-door Coupe and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. A faulty electrical contact within the seat position switch may prevent the driver and passenger air bags and seat belt force limiters from properly activating during a crash.

Consequence

Air bags and seat belts that do not perform properly in a crash can increase the risk of injury.

Remedy

MBUSA will notify owners, and dealers will replace the seat position switches, free of charge. Owner letters were mailed May 21, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040016.

21V228000Driver AssistanceApril 1, 2021 · 6 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, and AMG E63 vehicles. The parking control unit may fail to display the rearview camera image and cause the parking sensors to misidentify or fail to detect objects.

Consequence

An inoperative rearview camera display and/or parking sensors can reduce the driver's view and awareness of what is behind the vehicle, increasing the risk of a crash.

Remedy

All affected vehicles are still within MBUSA's control. MBUSA will replace the parking control unit, free of charge. The recall began April 8, 2021. Owner may contact MBUSA customer service at 1-800-367-6372.

21V216000SeatsMarch 26, 2021 · 109 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, E63S AMG, 2020 E63S AMG Wagon, and 2020-2021 E53 AMG vehicles. The passenger seat limiter may allow the seat to be positioned too close to the air bag.

Consequence

A seat too close to the air bag increases the risk of injury in the event of a crash necessitating the deployment of the frontal passenger air bag.

Remedy

MBUSA will notify owners, and dealers will recalibrate the passenger seat limiter, free of charge. The recall began April 29, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040002.

21V058000OtherFebruary 5, 2021 · 1,292,258 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2016 - 2021 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, GT-Class, C-Class, E-Class, S-Class, CLS-Class, SL-Class, B-Class, GLB-Class, GLC-Class, and G-Class vehicles. Please refer to the Part 573 report for specific vehicle model details. The software design of the communication module may fail to communicate the correct vehicle location for the emergency call system (eCall) in the event of a crash.

Consequence

Failure of the eCall system may result in emergency responders being dispatched to the wrong location, increasing the risk of injury following a crash.

Remedy

MBUSA will notify owners, and the communication module software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. The recall began March 12, 2021. Owners may contact MBUSA customer service at 1-877-762-8267. MBUSA's number for this recall is 2021020025.

20V673000SeatsOctober 30, 2020 · 1,337 units

Defect

Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2021 E350 and E450, 2019-2021 AMG E53 and 2020-2021 AMG E63 vehicles. The front passenger seat may be missing the mechanical seat adjustment range limit stop, allowing the seat to move outside of the acceptable range in relation to the air bag.

Consequence

If the front passenger seat is adjusted beyond the acceptable range in relation to the air bag, there could be an increased risk of injury in the event of a crash with air bag deployment.

Remedy

MBUSA will notify owners, and dealers will inspect for the mechanical seat adjustment range limitation for the front passenger seat and install it if necessary, free of charge. The recall began December 18, 2020. Owners may contact MBUSA customer service at 1-800-368-6372. MBUSA's number for this recall is 2020110013.

Consumer complaints filed with NHTSA

Representative excerpts, cleaned of personal information. These are consumer statements, not verified defects.

I was parking and the 360 view sensor did not come up. When I tried to back out and move forward again, I realized the back up camera would not come on. I turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative.

Complaint filed with NHTSA · Driver Assistance · May 16, 2024

FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to…

Complaint filed with NHTSA · Engine · December 2, 2024 · fire

FIRE FIRE FIRE Information light came on just saying 12 Volt Battery. I sat in the car letting it idle for about 3 minutes. It began to smoke and then burst into flames. I called 911 got the fire department here but by the time they were here there was not much left. The car essentially burned to…

Complaint filed with NHTSA · Electrical System · December 2, 2024 · fire

The contact owns a 2021 Mercedes-Benz E350. The contact stated while driving at approximately 60 MPH, the check engine warning light illuminated, and the vehicle decelerated to 30 MPH. The vehicle was taken to the local mechanic who diagnosed that the fuel pump was faulty and needed to be replaced.…

Complaint filed with NHTSA · Fuel System · January 18, 2024

The Mercedes E350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. I managed to exit the highway but the car could not be moved and left me stranded.

Complaint filed with NHTSA · Transmission · July 9, 2025

2021 Mercedes-Benz E 350 — common questions

Is the 2021 Mercedes-Benz E 350 reliable?

The record is thin — 19 NHTSA complaints — so owner-report data can't strongly confirm reliability either way, though 12 recalls should be verified as completed.

What are the most common 2021 E 350 problems?

According to NHTSA complaint data, the leading problem areas are driver assistance (5 complaints), engine (4 complaints), electrical system (4 complaints).

Does the 2021 Mercedes-Benz E 350 have recalls?

Yes — NHTSA lists 12 recall campaigns affecting the 2021 Mercedes-Benz E 350. Recall repairs are free at franchised dealers; check the VIN at nhtsa.gov/recalls to confirm the work was done.

Related

Based on NHTSA ODI data through June 2026. Complaints are consumer-reported and unverified. Updated July 5, 2026.

Compiled by Sharon Ben-Moshe, Founder.