VehicleVerdict

2022 Mercedes-Benz E 350 problems

Verdict · NHTSA data

Limited data — recalls on file

NHTSA has just 9 complaints on file for the 2022 Mercedes-Benz E 350 — too few to judge reliability from owner reports alone — but 3 recall campaigns apply to this year, so any used example should have its VIN checked for completed recall work.

9

NHTSA complaints

3

Recalls

0

Investigations

0

Crash-involved

0

Fires reported

0

Injuries

0

Deaths

—

NCAP overall

How does 2022 compare to other E 350 years?

E 350 NHTSA complaints by model year, 2022 highlighted19 complaints2020: 12 complaints2021: 19 complaints2022: 9 complaints2023: 5 complaints2024: 10 complaints2025: 4 complaints2026: 0 complaints
E 350 NHTSA complaints by model year, 2022 highlighted. Red bars are years to avoid.

See all E 350 years to avoid →

What are the most common 2022 Mercedes-Benz E 350 problems?

ComponentComplaintsShare
Other333%
Driver Assistance222%
Electrical System111%
Fuel System111%
Speed Control111%
Transmission111%

Does the 2022 Mercedes-Benz E 350 have recalls?

3 NHTSA recall campaigns on file. Recall repairs are free at franchised dealers.

23V880000Fuel SystemDecember 21, 2023 · 79,676 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2024 GLE, GLS, C-Class, E-Class, S-Class, SL, GLC, CLS, AMG GT, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, causing a loss of drive power.

Consequence

A loss of drive power can increase the risk of a crash.

Remedy

Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 28, 2024. Owner notification letters will be mailed in phases, on February 23, 2024, April 19, 2024, June 28, 2024, August 9, 2024, October 1, 2024, and December 2, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of NHTSA recall number 23V-445.

23V445000Fuel SystemJune 26, 2023 · 143,551 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.

Consequence

A loss of drive power can increase the risk of a crash.

Remedy

Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.

22V189000SteeringMarch 25, 2022 · 8,396 units

Defect

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.

Consequence

Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.

Remedy

Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.

Consumer complaints filed with NHTSA

Representative excerpts, cleaned of personal information. These are consumer statements, not verified defects.

“The panoramic sunroof exploded while inside the car without warning. Contacted the dealership/service center on Friday 9/15/2023, was told they have not received a memo regarding the panoramic sunroofs in the 2022 E350, however; this is a know problem. I was told that this is not covered of my…”

Complaint filed with NHTSA · Other · September 15, 2023

“Auto break suddenly activated during traffic with no obstruction ahead. Also Automatic Headlamp Mode Inoperative comes on and off”

Complaint filed with NHTSA · Driver Assistance · June 13, 2022

“Auto break suddenly activated during traffic with no obstruction ahead. Also Automatic Headlamp Mode Inoperative comes on and off”

Complaint filed with NHTSA · Electrical System · June 13, 2022

“Major issue found with engine cylinder head in various models with 2.0 Liter Turbo charged engines (Engine code M260 or M264). Cylinder heads have premature wear at valve seats, causing engine misfires and unsafe driving conditions. (Sudden loss of power, even on freeways.) Mercedes-Benz had…”

Complaint filed with NHTSA · Transmission · June 1, 2025

“The contact owns a 2022 Mercedes-Benz E350. The contact stated that on several occasions while driving at various speeds, the vehicle decelerated while the accelerator pedal was depressed. The contact was able to turn off and restart the vehicle. An unknown warning light was illuminated. The…”

Complaint filed with NHTSA · Fuel System · August 22, 2023

2022 Mercedes-Benz E 350 — common questions

Is the 2022 Mercedes-Benz E 350 reliable?

The record is thin — 9 NHTSA complaints — so owner-report data can't strongly confirm reliability either way, though 3 recalls should be verified as completed.

Does the 2022 Mercedes-Benz E 350 have recalls?

Yes — NHTSA lists 3 recall campaigns affecting the 2022 Mercedes-Benz E 350. Recall repairs are free at franchised dealers; check the VIN at nhtsa.gov/recalls to confirm the work was done.

Related

Based on NHTSA ODI data through June 2026. Complaints are consumer-reported and unverified. Updated July 5, 2026.

Compiled by Sharon Ben-Moshe, Founder.